Current seismic design codes do not contemplate explicitly some variables that are relevant for the design of structures subjected to ground motions exhibiting large energy content. Particularly, the lack of explicit consideration of the cumulative plastic demands and of the degradation of the hysteretic cycle may result in a significant underestimation of the lateral strength of reinforced concrete structures built on soft soils. This paper introduces and illustrates the use of a numerical performance-based methodology for the predesign of standard-occupation reinforced concrete ductile structures. The methodology takes into account two limit states, the performance of the non-structural system, and in the case of the life safety limit state, the effect of cumulative plastic demands and of the degradation of the hysteretic cycle on the assessment of structural performance.