This paper presents an appraisal of four nonlinear static procedures (CSM, N2, MPA and ACSM) employed in seismic assessment of plan-irregular buildings. It uses a three storey reinforced concrete plan-irregular frame building exemplifying typical older constructions of the Mediterranean region in the early 1970s that was tested in full-scale under bi-directional pseudo-dynamic loading condition at JRC, Ispra. The adequacy and efficiency of the simplified analytical modelling assumptions adopted were verified. In addition, the appropriate variants of code-prescribed NSPs (CSM and N2) to be considered for subsequent evaluation were established. Subsequent parametric studies revealed that all such NSPs predicted reasonably well both global and local responses, having the benchmark values been determined through nonlinear dynamic analyses using a suit of seven ground motions applied with four different orientations. The ACSM, however, predicted responses that matched slightly better the median dynamic results.