The prevalence of major zoonotic diseases such as tuberculosis, brucellosis and the highly pathogenic avian influenza (HPAI) in Jeonbuk province was monitored from 2004 to 2008. For tuberculosis, a total of 306 heads from 92 farms were positive during the surveillance period, which 228 heads were from 78 dairy farms and 78 heads from 14 Hanwoo farms. Based on the number of recurrent tuberculosis in 92 positive farms, 28 farms or 43.8% of the positive farms had 1-4 additional outbreaks during the surveillance. Based on brucellosis surveillance of 5,252 dairy cattle and 2,600,829 Hanwoo conducted during the same time period, 4,818 heads from 1,203 farms were positive for brucellosis, which 445 heads were from 111 dairy farms and 4,373 heads from 1,092 Hanwoo farms. Among the 1,203 positive farms, 473 farms or 39.3% of the positive farms had experienced 1-4 recurrent brucellosis during the surveillance. According to nationwide surveillance of HPAI, a total of 45 cases had been reported between 2004 and 2008. Among those outbreaks, 20 cases were reported in Jeonbuk province and 3 cases in 2006 and 17 case in 2008. For the regional distribution of 20 cases in Jeonbuk, 4 cases (48,490 chickens), 4 cases (23,066 chickens 66(1) and ducks 23,000(3)), 11 cases (183,077 chickens 63,077 (10) and quails 120,000 (1)), and 1 case (9,000 ducks) were reported in Iksan, Jeongeup, Gimje and Sunchang, respectively.