Objectives : The aim of this study was to evaluate the effect of acupuncture therapy on dry eye syndrome. Methods : We investigated 43 cases of patients with dry eye syndrome. They were treated with acupuncture therapy twice or three times a week. Symptoms score, number of dry eye symptoms, Ocular surface disease index were compared between eyes before and after treatment to evaluate the efficacy of acupuncture therapy. Results : After 24 times treatment, symptom score, number of dry eye symptoms, Ocular surface disease index were significantly decreased. Conclusions : Acupuncture therapy was effective to improve symptoms of dry eye syndrome patients. There should be more observation about patients with dry eye syndrome and further study will be needed.