Objectives : The acupoint-meridian relationship of an acupoint is one of important features of the acupoint. It has also shown evolutionary development over the history of medicine. This study analyzed the prototype kind of information on acupoint-meridian relationships in the A-B Classic of Acupuncture and Moxibustion(the Classic) of 2c BCE. Methods : The acupoint-meridian relationship of all the acupoints listed in the Classic was counted and reviewed in comparison with the information in the contemporary standard texts. Results : In comparison with the contemporary standard of 361 meridian points, the Classic listed 349(97%) acupoints. Of contemporary standard 361 points, 287(81%) acupoints still maintain the same acupoint-meridian relationship as in the Classic. Conclusions : Acupoint-meridian relationship in the Classic has largely been maintained throughout the history and still comprises a major proportion of the contemporary body of knowledge on acupoint-meridian relationship.