Objectives: The aim of this study was to investigate the association of social support and quality of life of stroke patients. Methods: Stroke patients were interviewed by a direct contact survey among 160 person. A structured questionnaire was configured about demographic features, social support and health related quality of life(SF12). Data were collected from July to August 2009. Results: Among social support, satisfaction of dependable when you need help is the highest score(5.3) and console you when you are very upset is the lowest(4.0). Vitality among health related quality of life(HRQOL) is the higest score(55.9) and general health score is the the lowest(17.4). Physical component score(PCS) is lower than mental component. The results of multiple regression analysis about the factors affecting the PCS and MCS score, disability grade and feel better variable gave effect HRQOL. Conclusions: For improvement of HRQOL, among stroke patients, community social support, specially, when patients feeling generally down-in-the dumps, the rely on to help feel better was needed.