This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL-60 human leukemia cells with $IC_{50}$ in values of 29.8 and 21.4 ${mu}M$ by the induction of apoptosis.