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Identification of Streptomyces sp. KH29, Which Produces an Antibiotic Substance Processing an Inhibitory Activity Against Multidrug-Resistant Acinetobacter baumannii
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  • Identification of Streptomyces sp. KH29, Which Produces an Antibiotic Substance Processing an Inhibitory Activity Against Multidrug-Resistant Acinetobacter baumannii
  • Identification of Streptomyces sp. KH29, Which Produces an Antibiotic Substance Processing an Inhibitory Activity Against Multidrug-Resistant Acinetobacter baumannii
저자명
Lee. Keyong-Ho,Kim. Gye-Woong,Rhee. Ki-Hyeong
간행물명
Journal of microbiology and biotechnology
권/호정보
2010년|20권 12호|pp.1672-1676 (5 pages)
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한국미생물생명공학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The Actinomycete strain KH29 is antagonistic to the multidrug-resistant Acinetobacter baumannii. Based on the diaminopimelic acid (DAP) type, and the morphological and physiological characteristics observed through the use of scanning electron microscopy (SEM), KH29 was confirmed as belonging to the genus Streptomyces. By way of its noted 16S rDNA nucleotide sequences, KH29 was found to have a relationship with Streptomyces cinnamonensis. The production of an antibiotic from this strain was found to be most favorable when cultured with glucose, polypeptone, and yeast extract (PY) medium for 6 days at $27^{circ}C$. The antibiotic produced was identified, through comparisons with reported spectral data including MS and NMR as a cyclo(L-tryptophanyl-L-tryptophanyl). Cyclo(L-Trp-L-Trp), from the PY cultures of KH29, was seen to be highly effective against 41 of 49 multidrug-resistant Acinetobacter baumannii. Furthermore, cyclo(L-Trp-L-Trp) had antimicrobial activity against Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Saccharomyces cerevisiae, Aspergillus niger, and Candida albicans, However, it was ineffective against Streptomyces murinus.