Objectives: This study was designed to understand the association between the perceived social support and the quality of life among cancer patients. Methods: Questionnaire survey was conducted from July 10 to August 14 in 2008 among inpatients and outpatients visited Gangwon Cancer Center. Survey was done for 429 patients who were diagnosed as cancer longer than two years and 232 patients responded. We used Multidimensional Scale of Perceived Social Support(MSPSS) and Euro Quality of Life-5 Dimension(EQ-5D). Results: Prevalence of problem in Quality of life among cancer patients were as follows; 28.6% in mobility, 26.0% in pain or discomfort, 24.8% in anxiety or depression, 22.7% in usual activity, and 15.7% in self-care. Cancer patients with higher social support had significantly higher Quality of Life. Also more severe stage had significantly lower Quality of Life. Conclusion: Education, income, stage, and social support seemed influential to Quality of Life among cancer patients. Programs are necessary to promote social support for Quality of Life especially for cancer patients diagnosed as higher stage. Counseling and supporting can be useful not only for patients but also for families.