Objectives: This study was conducted to estimate the health-related quality of life using EQ5-D by socio-demographic characteristics and mental health among Seoul citizens for developing health promotion programs. Methods: The study subjects using cluster-stratified sampling method were 1234 adults over 19 years old from 17 dong, S-Ku in Seoul City. A cross-sectional study with face-to-face interview was used to collect data. A questionnaire measuring socio-demographic variables, Symptom Checklist-90-Revised (SCL-90-R) and Euroqol EQ-5D instrument. The Difference on the EQ-5D index among groups were tested with Mann-Whitney U test and Kruskal Wallis test. Results: The mean EQ-5D index for all subjects was 0.946(${pm}0.105$). The EQ-5D index were significantly different by sex, age, marital status, eduction level and income. The EQ5-D indexes among clinical mental health groups were the lowest scores and significantly different from other groups. Conclusion: The findings suggest that the future intervention of health promotion programs should be carefully designed and tailored by socio-demographic variables. Especially, the mental health programs need to be developed.