Objectives: The aim of this study was to examine factors related to smoking behavior, and to develop multilevel communication strategies for smoking cessation. Methods: This paper reviewed theories and empirical findings with currents ecological models to develop communication strategies. Theory comparison was also performed to identify important mediators in the process of smoking cessation. Results: Factors that have been identified to influence smoking behavior ranges from individual perception, attitudes and self efficacy toward smoking to organizational norms, regulations, community capacity, media advocacy and public smoking regulation policy. In order to address these multi-level determinants of smoking behavior, objectives and strategies for smoking cessation intervention were developed utilizing ecological perspectives to cover intrapersonal, interpersonal(mainly family member and peers), organizational and community/public policy level factors. Conclusion: Multilevel approaches have advanced the existing knowledge on determinants of health behaviors. New direction of research focusing on testing multilevel intervention approaches should be expanded to inform the efficacy of applying social ecological models to health behavior change process.