In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5${alpha}$,6${alpha}$,7${eta}$,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-${eta}$-D-glucopyranoside (1), (5${alpha}$,6${eta}$,7${alpha}$,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-${eta}$-D-glucopyranoside (2), (5${alpha}$,6${eta}$,7${alpha}$,12${eta}$,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-${eta}$-D-glucopyranoside (3), and (5${alpha}$,6${eta}$,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-${eta}$-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.