A numerical analysis for the space frame structure under ballistic and blast loads was performed using LS-DYNA, a commercial code. The space frame structure was developed to be adapted to the ground vehicle in the future and it was designed to build with Al7039 frames and lightweight multi-layered panels for the purpose of weight reduction and shock mitigation. The analyses have done for side impacts by a cylindrical projectile and Comp. C-4 explosive representing major threats to the vehicle. The deformed shape of the panel section and stresses as well as accelerations of the frames calculated from LS-DYNA were compared to the test results to validate the analysis model. The internal energies for panels and frames from LS-DYNA were also compared to each other to discern their role in absorbing the ballistic and blast impact.