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Enzymatic Acrylation of 2-Hydroxy-${gamma}$-butyrolactone to Synthesize the Gamma Butyrolactone Methacrylate (GBLMA) for Photoresist
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  • Enzymatic Acrylation of 2-Hydroxy-${gamma}$-butyrolactone to Synthesize the Gamma Butyrolactone Methacrylate (GBLMA) for Photoresist
  • Enzymatic Acrylation of 2-Hydroxy-${gamma}$-butyrolactone to Synthesize the Gamma Butyrolactone Methacrylate (GBLMA) for Photoresist
저자명
Kim. Sang-Cheol,Nam. Dong-Hyun,Kim. Yong-Hwan,Song. Bong-Keun
간행물명
Biotechnology and bioprocess engineering
권/호정보
2010년|15권 2호|pp.208-212 (5 pages)
발행정보
한국생물공학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Lipase-mediated acrylation has gained much attention instead of traditional chemical process, since it enables specific catalysis under benign conditions. The effect of acyl donors on the acrylation of 2-hydroxy-${gamma}$-butyrolactone by Novozym 435 (immobilized lipase B from Candida antarctica) was investigated. Among acyl donors, vinyl methacrylate was selected to synthesize ${gamma}$-butyrolactone methacrylate (GBLMA). The effects of solvent and reaction temperature on the acrylation using vinyl methacrylate were presented. The highest rate of conversion was obtained using methyl tert-butyl ether (>80%) as a solvent, of which a log P value is greater than other solvents tested. The conversion rate increased as the reaction temperature rose from 30 to $60^{circ}C$ and the conversion rate approached 95% at $60^{circ}C$. The gamma butyrolactone methacrylate (GBLMA) synthesized with vinyl methacrylate at optimized conditions, in which MTBE is used as a solvent and the reaction is carried out at $60^{circ}C$ can be applicable as a monomer for synthesis of photoresist resin.