In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.