Objective: This study aimed to construct an overview of health-related quality of life (HRQOL) scales for application in studies of traditional Korean medicine (TKM). Methods: We analyzed all HRQOL scales from the PROQOLID web site (www.proqolid.org) regarding to classification, application purposes, and translation to Korean version. We also searched clinical studies focused on "Quality of Life" using TKM. Results: A total of 660 HRQOL instruments were analyzed; 99 were for general condition while 559 were disease-specific. Twenty clinical studies for TKM were conduced using HRQOL scales. Conclusion: The adaptation of the international HRQOL instrument is strongly recommended in TKM-associated clinical study, and development of a TKM-specific HRQOL scale is needed for globalization of TKM.