Pressure characteristics according to the duct shapes of turbo blowers connected in serial have been performed to reduce pressure loss in the piping system. To analyze three-dimensional flow field in the turbo blower system, general analysis code, CFX, is introduced in the present work. SST turbulence model is applied to estimate the eddy viscosity. Throughout the numerical simulation for the turbo blower system having a various shape of a inlet guide, optimal inlet guide can be selected. It is found that the pressure loss in the piping system having the optimal inlet guide can be reduced by minimizing the inflow distortion at the upstream of the impeller. Detailed flow analysis of the blower system serially connected is also performed and analyzed.