The purpose of this study is to analyze musculoskeletal injuries in combine harvesting operation using a digital human model. In order to analyze problems in combine harvesting operation, the operations were broken into 5 work processes and then we preformed ergonomic and biomechanical analyses such as RULA test, Comfort Assessment and joint kinetic analysis for the each process. As a result, there was a clear need to change the combine operating environment, as the RULA score ranged from 4 to 7. In addition, we could find two major musculoskeletal injury factors which are the standing posture with upperbody forward tilting and inappropriate location of operating levers.