Purpose: This study was designed to explore and compare the self efficacy, social support, and quality of life between middle-aged Korean and Chinese women. Methods: The sample included 430 (Korean: 220, Chinese: 210) middle-aged women. Study instruments were the Self Efficacy Scale developed by Shere et al (1982), the Social Support Scale modified and based on Interpersonal Support Evaluation List (ISEL) developed by Cohen and Hoberman (1983), and The Quality of Life Scale (SF-36) developed by Ware and Book (1981). Data were analyzed by SPSS/WIN 16 version. Results: Korean women reported more self efficacy and better quality of life than the Chinese women. The quality of life scores between middle-aged Korean and Chinese women showed a statistical significant difference. Self efficacy and quality of life scores reported by middle-aged Korean and Chinese women were below the reported standards of the instruments. In contrast to the other scores, Chinese women reported more social support than Korean women. Conclusion: The findings add to the body of literature about Chinese and Korean middle aged women. Additional research is needed to explain the differences among the two groups but the findings can inform the practicing nurse who works with these populations.