Purpose: The purpose of this study was to identify the reported factors influencing fatigue of middle aged women. Methods: Two hundred seven middle aged women between 40 and 59 years of age were recruited from five areas in Korea from March 1, 2010, to April 20, 2010. Data were collected by self-reported questionnaires. Data analysis was done using SPSS/WIN 15.0 program for descriptive statistics, Pearson correlation coefficients and stepwise multiple regression. Results: The average score of fatigue was $2.34{pm}0.40$. There were significant differences in reported fatigue according to economic status and health status. The reported fatigue was significantly correlated with somatic attribution, psychological attribution, normalizing attribution, depression, marital adjustment, stress, and social support. The major factors that affect fatigue in middle aged women were stress, depression, and normalizing attribution, which explained 32.3% of fatigue. Conclusion: The findings can reduce the fatigue by controlling stress and depression. Additionally, this study can understand the attribution of fatigue in middle aged women. More studies are needed to identify other variables that influence on the fatigue of middle aged women.