Purpose: This study investigated the effects of Web-Contents Learning by nursing students on nursing knowledge, self-directed learning and clinical competence. Method: This study was a quasi-experimental, nonequivalent control group pre-post test. For the study, 146 nursing students were selected from three colleges. Seventy-six were experimental subjects and 70 were control subjects. The subjects in the experimental group studied Web-Contents along with four weeks of clinical practice. Data were collected by structured questionnaires and analyzed using the SPSS program. Result: The experimental group showed significant increase in their nursing knowledge (t=-3.866, p=.001). However, no significant differences were observed between the two groups in self-directed learning (t=-.759, p=.449) and clinical competence (F=.891, p=.347). Conclusion: From our investigation, the present study suggests some implication for learner-related variables. Elaboration of experimental design to validate the effects of Web-Contents Learning should be carried out.