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Aldose Reductase Inhibition Effect of PhenolicvCompounds Isolated from Paulownia coreana Bark
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  • Aldose Reductase Inhibition Effect of PhenolicvCompounds Isolated from Paulownia coreana Bark
  • Aldose Reductase Inhibition Effect of PhenolicvCompounds Isolated from Paulownia coreana Bark
저자명
Kim. Jin-Kyu,Lee. Yeon-Sil,Lim. Soon-Sung,Bae. Young-Soo
간행물명
목재공학
권/호정보
2010년|38권 2호|pp.159-164 (6 pages)
발행정보
한국목재공학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Nine compounds, caffeic acid, naringenin, apigenin, luteolin, kaempferol, verbascoside, isoverbascoside, isocampneoside II, and cistanoside F, were isolated from the EtOAc and n-BuOH fractions of P. coreana bark. The structures of these compounds (1-9) were elucidated by spectroscopic methods and literature data. All the isolates were subjected to in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among these, compounds 6 and 8 indicated the significant inhibitory activity on rat lens aldose reductase with $IC_{50}$ values of 2.67 and 5.59 ${mu}M$, respectively. Especially, The inhibition activity of acteoside was 3.9 times better than that of quercetin as a positive control (10.6 ${mu}M$). These results suggested that phenylethanoid glycosides are likely to be the potential compounds for the prevention and/or treatment of diabetic complications.