McDonald 2.1m Otto Struve Telescope is located in the Davis Mountains, 450 miles west of Austin, Texas. The telescope was built in 1938, but it is still in demand today. CQUEAN (Camera for QUasar in Early uNiverse) will be attached on this telescope and perform Y-band imaging observations. Dynamics study of the telescope shows that tracking errors are 0.1 arcsec/100sec in declination direction and 0.4 arcsec/100sec in R.A. direction. In order to allow a long exposure (> a few minutes) of a target field, we are making auto-guiding system for the 2.1m telescope. The auto-guiding system of CQUEAN will be connected with TCS of the telescope. The expected number of stars on the CCD field (2.97 square arcminutes) is about 1.2 stars which are brighter than magnitude 17.5 in 2.97 square arcminutes. For more effective observation, we plan to implement moving mechanism in guiding system so that guide CCD camera can see wider off-axis fields.