Base-mounted type(BMT) driving assembly in CNC machine tools is an indispensable part to improve productivity by reducing tool changeover time and to meet the ever-increasing demand of precision machine tools. This study aimed to perform finite element analysis and geometric parameter optimization to improve the efficiency of BMT driving assembly. First, simulations for three-dimensional structural and vibration analysis were performed using ANSYS/Workbench on the initial geometric models of BMT driving assembly. After analyzing stress and deformation concentration zones, several new geometrical models were designed and evaluated by design of experiments and ANSYS/DesignXplorer. Through a series of analysis-evaluation-modification cycles, it was seen that designed models were effective in determining optimal geometry of BMT driving assembly.