The association between five limpness(五軟), five stiffness(五硬), five retardation and disease have been repeatedly shown in patient. However, comparative study has been rare. This study arrange disease, which answer to five limpness, five stiffness, five retardation and classify by epiologic diagnosis. We search for scientific journals, medical college texts, theses of a degree and collect case reports. In this study we found that the five retardation(N=56) is showing numerous more than the others. The five stiffness(N=14) is showing rare than the five limpness(N=29). The five limpness is overlapping more than 90% with five retardation. and the five stiffness is overlapping 80% with five retardation. Symptom of five limpness, five stiffness, five retardation is coming out independent and overlapping each others. And generally it accompanies with abnormality in central nervous system.