Objective: To obtain an overview of the status of health-associated factors of Korean high school adolescents. Methods: 2,455 high school students (1,808 boys and 647 girls) filled out questionnairesfor their health-related factors such as physical problems, sleep and exercise. Results: Students sleep about 5.5 hours per day while they exercise only 2.6 hours each week. 14.2% of students skip breakfast every day. 31.0% of students were under severe stress, and 46.4 % has at least one symptom of distresses such as indigestion, headache, frequently catching cold, or muscle pain. 40.7% of the students took a functional supplement, especially vitamins as the most common, and ginseng and herbal drugs as the second and third. Conclusion: These results present general health-associated status of high school students, thus they could be helpful to design medicinal strategies for high school students using traditional Korean medicine.