Objectives : The aim of this study was to investigate the correlation between the effectiveness of Brief Qigong-based Stress Reduction Program(BQSRP) and personality. Methods : Twenty nine women and nine men from the community with symptoms of distress(mean age 39.4 years, SD=11.4) were randomized into a group receiving a 4-week intervention of BQSRP(n=19) or a waiting-list control group. All subjects completed the temperament and character inventory (TCI) before the intervention. Before and after the intervention period, questionnaires were completed on perceived stress scale(PSS), anxiety, and quality of life. Results : 1. Those who have higher temperament of harm avoidance or lower character of self-directedness showed higher PSS, Hwa-Byung character, Hwa-Byung symptom, STAI and lower WHOQOL-BREF scores. 2. In the BQSRP training group, a correlation analysis demonstrated an association between higher temperament of harm avoidance and greater improvement of perceived stress and an association between lower character of self-directedness and greater improvement of perceived stress. 3. Those who have high Hwa-Byung symptom scores prefer the breathing meditation and there were no differences in effects of BQSRP group by the preference Brief Qigong-based Meditation(BQM) component. Conclusions : These results suggest that a BQSRP training may be effective for those with higher harm avoidance trait and low self-directedness.