The smallpox or chanjin(瘡疹), from Korea Dynasty when the name concretely is discussed to Joseon Dynasty, was very one of the diseases which were important. Not only the public but also the royal family could not avoid the pain which is caused by with the smallpox. Also as a scar and fear that the smallpox leave on, the smallpox was called a God(痘瘡神). As the prayer and sacrificial rites primarily could not relieve the nation and the community from a smallpox, an intellectual finally had to remind that if people considered a factor which caused the smallpox, they could cure this disease. That was Nam Hyoon(南孝溫) who rejected a goast to cause a smallpox. And the compilation of "Changjinjip(瘡疹集)" changed recognition about a smallpox. Especially, the compilation of "Changjinjip" was very important in the history of Korean medicine. Because it told what "Uibanglyuchui(醫方類聚)" the national compilation project of medicine book that King Sejong promoted leaved. The "Changjinjip(瘡疹集)" adopted two kind methods. The one was the medical history or with medical theoretic history method: arranged a various medical theory about "changjin" like "Uibanglyuchui". The other was the clinical method of presenting theories and prescriptions as causes and mutations: reformed contents of "Uibanglyuchui". In addition to special medicine book of smallpox, "Changjinjip" gave knowledge about a paradigm of "Uibanglyuchui" and methods of medical book compilation in later.