Because both R-134a and R-600a are used as a refrigerant of a household refrigerator in the global market, the home-appliance industry needs an optimized cycle for both refrigerants. The objective of this study is to provide the design guideline on the optimization of a refrigeration system using both refrigerants. For both refrigerants, the performance characteristics of the refrigeration system were tested by varying refrigerant charge amount, capillary tube length, suction diameter and SLHX length. The tested refrigeration system was optimized at the refrigerant charge of 60 g and the capillary tube length of 3600 mm with R-134a, and the refrigerant charge of 34 g and the capillary tube length of 3900 mm with R-600a. The COP increased from 1.63 to 1.68 for R-134a and increased from 1.37 to 1.48 for R-600a, respectively, by applying the suction diameter expansion. In addition, the COP of the R-134a and R-600a system decreased by 2.3~2.4% as the SLHX length decreased by 300 mm.