Plate cam mechanism can easily produce the positive and functional motions in contact of cam and follower. Generally cam mechanism is used in many fields of mechanical control, automation, and industrial machinery. To obtain the accurate motion of follower, the profile of cam must be designed and machined precisely. This paper proposes an instant velocity center method for the profile design and a biarc fitting method for the profile machining to 4 different types of plate cam mechanisms with reciprocating or oscillating motion and roller or flat-faced followers. The key of this paper is the introduction of a hybrid system combined the design procedures and the manufacturing procedures. The main idea is that the minimum machining data are built by the accurate biarc curves fitted directly from the design parameters. The radial direction angles toward biarc centers for the accurate biarc curve fitting can be defined directly by the contact angle of cam and follower given in the design procedures. An application of the proposed approach is verified the accurate profiles of a designed cam and a machining cam using the minimum NC data within a given machining tolerance.