Purpose: The purpose of this study was to investigate the effects of isokinetic exercise on muscular performance and thickness of the quadriceps muscle. Methods: Twenty one healthy male students participated in this study. Participants were divided into 2 groups: $60^{circ}/sec$ of isokinetic exercise (n=7), $180^{circ}/sec$ (n=7) and $300^{circ}/sec$ (n=7). Each group did isokinetic exercises 3 times a week for 6 weeks. Each group was measured for peak torque per body weight, average power and total work using a Biodex System 4. Rectus femoris, vastus laterails and vastus medialis were measured for muscle thickness using a SONOACE 6000C. Data were analyzed by repeated measures ANOVA using SPSS 12.0. Results: There was a significant time-related effect in peak torque per body weight, average power and total work. There was a significant time-related effect in the vastus medialis and rectus femoris muscle thickness. However, there was a significant group by time interaction for vastus laterlis muscle thickness. Conclusion: Isokinetic exercise may be an effective method for improving quadriceps muscle performance regardless of angular velocity. However, the thickness of the rectus femoris and vastus medialis muscle may be increased regardless of the angular velocity of the quadriceps muscle the vastus lateralis muscle may only be remarkably improved when doing exercise with low angular velocity.