Chordoma was described in the tail masses of two ferrets. Tail masses were surgically removed and submitted for diagnosis. On histopathology, the masses from both ferrets were almost similar each other. The mass was well-demarcated and composed of lobules or sheets of neoplastic cells. The neoplastic cells were round to polygonal with distinct cell border and contained marginally located round nucleus. The cytoplasm of neoplastic cells was highly vacuolated. Immunohistochemically, the neoplastic cells were positive to cytokerain, vimentin, and S-100. Based on these results, both cases were diagnosed as chordoma in ferrets. Recurrence was not noted since surgery.