Purpose: To investigate the effect of smoking cessation expectation and on the stress for subjects in smoking cessation clinic and effect of self-efficacy in the relationship between expectancy and stress, with the aim of establishing an effective management smoking cessation strategy. Methods: Current smokers (n=161) >30-years-of-age who were residents of G city completed a questionnaire. Results: Concerning the effect of self-efficacy and the expectancy on stress, they were significantly effective in first, second and third stage, and appeared 8.3% in first stage, 13.8% in third stage, showing self-efficacy has a controlling effect on stress. Conclusion: Smoking cessation expectancy and self-efficacy significantly influence stress, and must be taken into account in development of smoking-cessation strategies and programs.