The influent and effluent baffle configurations seriously affect the hydraulic characteristics of the secondary clarifier in wastewater treatment plant. In this study, those baffle configurations were optimized by computational fluid dynamics(CFD) analysis and particle image velocity(PIV) test in order to obtain uniform flow in inlet region and to minimize upflow velocity in outlet region of the secondary clarifier. Theoretical analysis using CFD showed that more uniform flow could be accomplished when the influent baffle was located closely to the inlet opening. Effects of effluent baffle configuration on the upflow velocity in the outlet region of the secondary clarifier were analyzed with four types of effluent baffles which are widely adopted for secondary clarifier design. From the CFD analysis, McKinney baffle(EB-2) was estimated to be the most effective for restraining the upflow velocity in the outlet region and these trends were identified by PIV tests. In addition, the McKinney baffle showed the most uniform overflow velocity distribution around the weir.