Purpose: The purpose of this study was to investigate relations among lifestyle, depression and health-related quality of life (HRQoL) of adult women in the Jeju Province. Methods: This study sampled 154 women aged 20 or older through convenience sampling and surveyed them from January to February, 2008. Results: The mean score for lifestyle was 3.7, for depression 12.1, and for HRQoL 75.2. There were significant negative correlations between lifestyle and depression, and between depression and HRQoL. There was a significant positive correlation between lifestyle and HRQoL. Conclusion: The results indicate that HRQoL of women is associated with lifestyle and depression. When developing programs to enhance health in women, consideration should be given to lifestyle and depression.