Purpose : The purpose of this study was to investigate a modified maneuver for quadriceps setting exercise for patients with knee osteoarthritis. Methods : The patients were randomly divided into a modified maneuver for quadriceps setting exercise group(MQG) and conventional quadriceps setting exercise group(CQG). Total of 28 patients received a modality with training for 1 hour, three times a week for 12 weeks. Results : Each group showed significant reductions in the WOMAC(Western Ontario McMaster Universities Osteoarthritis) Index, mobility, and muscle strength after 12 weeks. In pain, physical function, and hamstring muscle strength, there was a statistically significant difference between groups. Conclusion : According to the results, MQG experienced less pain, physical function, and increased more hamstring muscle strength than NQG.