In this paper, a two-phase structural health monitoring system using acceleration response signatures are presented to firstly alarm the change in structural condition and to secondly detect the changed location for full-scale concrete girder bridges. Firstly, Mihocheon Bridge which is a two-span continuous concrete girder bridge is selected as the target structure. The dynamic response features of Mihocheon Bridge are extracted by forced vibration test using bowling ball. Secondly, the damage alarming occurrence and the damage localization techniques are selected to design two-phase structural health monitoring system for Mihocheon Bridge. As the damage alarming techniques, auto-regressive model using time-domain signatures, correlation coefficient of frequency response function and frequency response ratio assurance criterion are selected. As the damage localization technique, modal strain energy-based damage index method is selected. Finally, the feasibility of two-phase structural health monitoring systems is evaluated from static loading tests using a dump truck.