An experimental investigation is conducted here to study the effects of applying frictional sliding fuses (FSF) in concrete infilled steel frames. Firstly, the influences of some parameters on the behavior of the sliding fuse are studied: Methods of adjusting the FSF for a certain sliding strength are explained and influences of time duration, welding and corrosion are investigated as well. Based on the results, time duration does not significantly affect the FSF, however influences of welding and corrosion of the constitutive plates are substantial. Then, the results of testing two 1/3 scale single-storey single-bay concrete infilled steel frames having FSF are presented. The specimens were similar, except for different regulations of their fuses, tested by displacement controlled cyclic loading. The results demonstrate that applying FSF improves infill behaviors in both perpendicular directions. The infilled frames with FSF have more appropriate hysteresis cycles, higher ductility, much lower deteriorations in strength and stiffness in comparison with regular ones. Consequently, the infills, provided with FSF, can be regarded as an engineered element, however, special consideration should be taken into the affecting parameters of their fuses.