Interference scenarios and methodologies between a terrestrial mobile service (MS) system and mobile-satellite service (MSS) system in a co-channel environment are established. Taking into account a practical deployment situation for both systems, we perform computational simulation of interference in terms of carrier-to-interference ratio (C/I) and interference-to-noise ratio (I/N) to evaluate the cofrequency interference from an MS system into an MSS system, and from an MSS system into an MS system, respectively. The methodology and results can be used as a guide when planning the deployment of MSS and MS systems with no unacceptable interference impact between them.