Purpose: The purpose of this study was to investigate the effects of an integrated management program on climacteric symptoms and depression in middle-aged women. Methods: A nonequivalent control-group design was used. The subjects consisted of 65 middle-aged women with climacteric symptoms. The experimental group (n=33) participated in the program for six 60-min sessions. To measure the climacteric symptoms and depression level of the subjects, two self-reporting questionnaires were used. Data were analyzed using SPSS Statistics 17.0 program. Results: The women in the experimental group reported the average score of 13.80 in climacteric symptoms, 14.38 in depression. The hypothesis that the climacteric symptoms of experimental group would be reduced more than that of the control group was supported (t=3.92, p<.001): physical symptoms (t=4.04, p<.001); psychological symptoms (t=1.80, p=.077); sexual symptoms (t=2.85, p=.006). The second hypothesis that the degree of depression of the experimental group who used the integrated climacteric symptoms management program would be reduced more than that of the control group was also supported (t=2.30, p=.02). Conclusion: The integrated management program for middle-aged women with climacteric symptoms was effective in reducing their climacteric symptoms and depression level.