By developing a linear algebra program involving many different structures associated to a three-graded H*-algebra, it is shown that if L is a Lie triple automorphism of an infinite-dimensional topologically simple associative H*-algebra A, then L is either an automorphism, an anti-automorphism, the negative of an automorphism or the negative of an anti-automorphism. If A is finite-dimensional, then there exists an automorphism, an anti-automorphism, the negative of an automorphism or the negative of an anti-automorphism F : A $ ightarrow$ A such that $delta$:= F - L is a linear map from A onto its center sending commutators to zero. We also describe L in the case of having A zero annihilator.