In this paper, a transmitter-based multipath processing and inter-channel interference (ICI) cancellation scheme for a ultra-wideband (UWB) spatial multiplexing (SM) multiple input multiple output (MIMO) system is presented. It consists of taps delayed lines and zero-forcing (ZF) filters in the transmitter and correlators in the receiver. For a UWB SM MIMO system with N transmit antennas, M receive antennas, and Q resolvable multipath components, the BER performance of a linear transmit ZF scheme is analyzed in a log-normal fading channel and also compared with that of a receiver-based ICI rejection approach. It is found that when M ${leq}$ N, the transmit ZF processing approach outperforms the ZF receiver while making the mobile units low-cost and low-power.