Purpose: The purpose of this study was to examine the effects of a hospice and palliative care education program including meaning in life on attitudes to end-of-life care and meaning in life for nursing students. Methods: This study used a quasi-experimental and non- synchronized with a non-equivalent control group design. The experimental group (n=28) participated in a hospice and palliative care education program including meaning in life. The control group (n=28) participated only in a hospice and palliative care education program. The 30-hour course examined hospice and palliative nursing care and logotherapy. Data were collected using a structured questionnaire consisting of general characteristics, attitudes to end-of-life care, and meaning in life. Collected data were analyzed for frequency, percentage, ${chi}^2$-test, and t-test using SPSS 19.0 WIN Program. Results: Scores for the attitude towards end-of-life care in the experimental group were significantly higher than in the control group. The meaning in life scores in the experimental group were significantly higher than in the control group. Conclusion: These findings suggest that the hospice and palliative care education program, including meaning in life, was effective in enhancing the attitude to end-of-life care and meaning in life among nursing students.