This paper deals with effects of certain important factors in a tube drawing operation, such as the use of a mandrel, die radius and tangential angle at die outlet, on the deformation behavior of a small-diameter seamless tube. Both experimental and finite element simulation studies are carried out to assess the effects of the above parameters. Experiments and finite element predictions are compared. The use of a mandrel simplifies the design of tube drawing, but also induces some difficulties from increased process complexity. The effects of die outlet tangential angle and radius are discussed in detail.