Since commercial operation of Kori-1 nuclear power plant in 1978, twenty units are under operation and six units are under construction at 2011 present. Nuclear power become a main energy source in our country. However, the plant was constructed by a USA vendor in its beginning period, the Quality Assurance requirements of USA was applied. Even though Quality Assurance requirements were newly established to the Korea Atomic Energy Act, its contents are quite similar to those of USA. And 10 CFR 50 App.B, ASME NQA-1 apply to most of nuclear industries as a quality assurance plan. In this paper, Quality Assurance requirement of domestic nuclear industries has been investigated and applicable method of ISO Quality Assurance application to the nuclear industries is suggested by a comparison ISO 9000 and nuclear quality assurance specification.