Cartesian robot control is an appealing scheme because it avoids the computation of inverse kinematics, in contrast to joint robot control approach. For tracking, high computational load is typically required to obtain Cartesian robot dynamics. In this paper, an alternative approach for Cartesian tracking is proposed under assumption that robot dynamics is unknown and the Jacobian are uncertain. A neuro-sliding second order mode controller delivers a low dimensional neural network, which roughly estimates inverse robot dynamics, and an inner smooth control loop guarantees exponential tracking. Experimental results are presented to confirm the performance in a real time environment.