Large eddy simulation(LES) of fully developed turbulent pipe flow has been performed to investigate the effect of Reynolds number on the flow field at $Re_{ au}$=180, 395, 590 based on friction velocity and pipe radius. A dynamic subgrid-scale model for the turbulent subgrid-scale stresses was employed to close the governing equations. The mean flow properties, mean velocity profiles and turbulent intensities obtained from the present LES are in good agreement with the previous numerical and experimental results currently available. The Reynolds number effects were observed in the mean velocity profile, root-mean-square of velocity fluctuations, Reynolds shear stress and turbulent viscosity.