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SABA (secondary structure assignment program based on only alpha carbons): a novel pseudo center geometrical criterion for accurate assignment of protein secondary structures
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  • SABA (secondary structure assignment program based on only alpha carbons): a novel pseudo center geometrical criterion for accurate assignment of protein secondary structures
  • SABA (secondary structure assignment program based on only alpha carbons): a novel pseudo center geometrical criterion for accurate assignment of protein secondary structures
저자명
Park. Sang-Youn,Yoo. Min-Jae,Shin. Jae-Min,Cho. Kwang-Hwi
간행물명
BMB reports
권/호정보
2011년|44권 2호|pp.118-122 (5 pages)
발행정보
생화학분자생물학회
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정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Most widely used secondary structure assignment methods such as DSSP identify structural elements based on N-H and C=O hydrogen bonding patterns from X-ray or NMR-determined coordinates. Secondary structure assignment algorithms using limited $C{alpha}$ information have been under development as well, but their accuracy is only ~80% compared to DSSP. We have hereby developed SABA (Secondary Structure Assignment Program Based on only Alpha Carbons) with ~90% accuracy. SABA defines a novel geometrical parameter, termed a pseudo center, which is the midpoint of two continuous $C{alpha}s$. SABA is capable of identifying $alpha$-helices, $3_{10}$-helices, and $eta$-strands with high accuracy by using cut-off criteria on distances and dihedral angles between two or more pseudo centers. In addition to assigning secondary structures to $C{alpha}$-only structures, algorithms using limited $C{alpha}$ information with high accuracy have the potential to enhance the speed of calculations for high capacity structure comparison.