This study was to investigate the effects of percussion program on depression and self-esteem for the elderly lived in residential care. 12 older adults participated in the 40-min. percussion program for 4 weeks(10 sessions). The percussion program consisted of three steps; 1) introduction for creating rapport and relationship, 2) process for mood induction and increasing interaction, and ending for increasing self-achievement and confirming the changed mood. Korean Geriatric Depression Scale (KGDS) and Self-Esteem Scale (SES) were administered before the first session and after the completion of the program. Results showed statistical significance (p<.05) in KGDS (p=.020) and SES (p=.025). Findings imply that percussion program can induce positive changes in depression and self-esteem for elderly in the residential care, and more depressed elderly group may have better outcome in percussion playing. Future studies should consider various levels of depression among elderly, and design the program to be more sensitive to the level of functioning.