Objectives : This study aimed to explore the passive multi-channel time series analysis method by measuring bio-potentials of acupuncture point and the peripheral region Methods : Bio-potential was measured at ST36 and the peripherical region of ST36 of 5 healthy volunteers at three times. The diagram of the potential changes over time were smoothed by moving average method and similarities of ST36 and the other points were calculated. Results : In the normal weight group, bio-potential similarity tended to decrease in proportion to the distance from the acupuncture point. In the obesity group, bio-potential similarity appeared in a very wide area. Bio-potential similarity had positive correlation with BMI value. Conclusions : The passive multi-channel time series analysis method showed the possibility be appropriate for the electrical characteristics study of meridians.